Superfine powder of Fibrates lipid-lowering drug and preparation method therefor

• Main Authors: MAO YUFENG, ZHANG ZHAOYONG, CHEN JIAO, YUE LIQUN
• Format: Patent
• Language: English
• Published: 06.01.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to superfine powder of a Fibrates lipid-lowering drug and a preparation method therefor. The Fibrates lipid-lowering drug is a main therapeutic drug for resisting hyperlipidemia, and due to influence resulting from factors such as relatively poor water solubility and the like, the bioavailability of the Fibrates lipid-lowering drug is not high. The method for preparing the superfine powder of the Fibrates lipid-lowering drug, provided by the invention, comprises the steps of applying ultrasonic waves, of which the frequency is 10kHz to 500kHz, the power is 1mW to 5,000W and the sound intensity is 0.1mW/cm to 500W/cm , to a Fibrates lipid-lowering drug containing homogeneous solution so as to rapidly obtain Fibrates lipid-lowering drug crystals, and then, carrying out normal operations such as solid collecting, washing, drying and the like, thereby directly obtaining the superfine powder of the Fibrates lipid-lowering drug. According to the superfine powder prepared by the method, the bioavailability of the drug is improved, the dosage of the drug is reduced, the solubility of the drug is improved, and the drug absorption can be enhanced, so that the application is wider.