1,3-dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury
The present invention relates to compounds of formula I: for use in treating pulmonary arterial hypertension and associated conditions, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or...
Saved in:
Main Authors | , |
---|---|
Format | Patent |
Language | English |
Published |
04.11.2015
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The present invention relates to compounds of formula I: for use in treating pulmonary arterial hypertension and associated conditions, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl, -alkylaryl or -alkylheteroaryl; X signifies CH2, oxygen atom or sulphur atom; n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2; and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof. |
---|---|
AbstractList | The present invention relates to compounds of formula I: for use in treating pulmonary arterial hypertension and associated conditions, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl, -alkylaryl or -alkylheteroaryl; X signifies CH2, oxygen atom or sulphur atom; n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2; and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof. |
Author | BONIFOCIO MARIA JOAO MACEDO DA SILVA SOARES DA SILVA PATRICIO MANUEL VIEIRA ARAUJO |
Author_xml | – fullname: BONIFOCIO MARIA JOAO MACEDO DA SILVA – fullname: SOARES DA SILVA PATRICIO MANUEL VIEIRA ARAUJO |
BookMark | eNqNjLkOwjAQRF1AwfUPS4-lHIoEJYpAVFT00QpviJGztnxECl-PCz6Aakaa92YtFmyZViKVh1oqPczKWz1qhR9rSFYyDjrvoMjrCaOeKEBvPaRAoBniQBA9YRyJI9geXDKjZfQzoI_ZQQPD7Ch3DvkIkBWYxK8sv5Oft2LZowm0--VG7K-XR3uT5GxHweGTmGLX3suiKarmeGrO9T_MFzGZRyk |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
ExternalDocumentID | CN105025895A |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_CN105025895A3 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 14:40:42 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_CN105025895A3 |
Notes | Application Number: CN201380059547 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151104&DB=EPODOC&CC=CN&NR=105025895A |
ParticipantIDs | epo_espacenet_CN105025895A |
PublicationCentury | 2000 |
PublicationDate | 20151104 |
PublicationDateYYYYMMDD | 2015-11-04 |
PublicationDate_xml | – month: 11 year: 2015 text: 20151104 day: 04 |
PublicationDecade | 2010 |
PublicationYear | 2015 |
RelatedCompanies | BIAL-PORTELA & CA, S.A |
RelatedCompanies_xml | – name: BIAL-PORTELA & CA, S.A |
Score | 3.0131407 |
Snippet | The present invention relates to compounds of formula I: for use in treating pulmonary arterial hypertension and associated conditions, where R1, R2 and R3 are... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | 1,3-dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151104&DB=EPODOC&locale=&CC=CN&NR=105025895A |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEB5qFfWmVdH6YAXpyUViHk0PRWzSUoSmRar0VnazW5pSk5KHUn-9s0sfXvQWErJshm925svOfAtwx7gUrjTrFNFjUashHOpyXqcIaNtmRp2ZjmpO7gVO9816GdmjEszWvTBaJ_RLiyOiR4Xo77lerxfbn1i-rq3MHniEt5KnzrDp11bsGMOXOs3WbzXbg77f92qe1_SCWvCKua6N0d1t2M87sKvSaKWz335vqa6Uxe-Q0jmCvQGOFufHUJJxBQ689clrFdjvrTa88XLle9kJFMa9SUU0XYo0iT4iwb6TuaSPNJ8qsSEiEEqfWsU7I5iIkiKTJIoJ5ndkU0xOkglZFHNEHkuXRFdzIvzIFLloqivZk5iwWJA5rgD48gztfQq3nfbQ61Kc_3hjrLEXbD_VPINyjFM4B-JwNuFIbdxQIiELDTdEOmpPXMtoSLXzdgHVv8ep_vfwEg6V4XV_nnUF5Twt5DUG6pzfaAv_ACO2mbQ |
link.rule.ids | 230,309,786,891,25594,76903 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT8IwEL8gGvFNUaP4VRPDk42Z--SBGOkgqDCIQcMb2dYSRnAj-9DgX--t4cMXfVu6rGlvv-vdr727Aty4nuCWUE2K6NGoVuMGtTzPpAhoXXcV01WNPDm56xjtN-15qA8LMF3lwsg6oV-yOCJqlI_6nsr1er7ZxLJlbGVy5wXYFD20BnW7umTHaL7y22ztRr3Z79k9VmWszpyq84q-ro7W3arpj1uwbSIllFTpvZFnpcx_m5TWPuz0sbcwPYCCCMtQYqub18qw210eeOPjUveSQ8iUW5XyYLLgcRR8BNz9jmaC3tN0khcbIhyh9CmreCcEHVGSJYIEIUH_jqyDyUk0JvNshshz4wWR0ZwIPzJBLhrLSPYoJG7IyQxXAPx4ivI-gutWc8DaFMc_WgtrxJzNVNVjKIY4hBMghueOPaQ2li-QkPmK5SMd1ceWptREfvJ2CpW_-6n89_IKSu1BtzPqPDkvZ7CX_wSZq6edQzGNM3GBRjv1LqW0fwB5g5ye |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=1%2C3-dihydroimidazole-2-thione+derivatives+for+use+in+the+treatment+of+pulmonary+arterial+hypertension+and+lung+injury&rft.inventor=BONIFOCIO+MARIA+JOAO+MACEDO+DA+SILVA&rft.inventor=SOARES+DA+SILVA+PATRICIO+MANUEL+VIEIRA+ARAUJO&rft.date=2015-11-04&rft.externalDBID=A&rft.externalDocID=CN105025895A |