Fluoroalkyl-1,4-benzodiazepinone compounds
Disclosed are compounds of Formula (I): wherein: R2 is phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, or pyridinyl; R3 is H, CH3, CH2(cyclopropyl), pyridinyl, chloropyridinyl, or methoxypyridinyl: and Ra, Rb, y, and z are defined herein. Also disclosed are methods of using su...
Saved in:
Main Authors | , , , , , , , |
---|---|
Format | Patent |
Language | English |
Published |
05.08.2015
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Disclosed are compounds of Formula (I): wherein: R2 is phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, or pyridinyl; R3 is H, CH3, CH2(cyclopropyl), pyridinyl, chloropyridinyl, or methoxypyridinyl: and Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer. |
---|---|
AbstractList | Disclosed are compounds of Formula (I): wherein: R2 is phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, or pyridinyl; R3 is H, CH3, CH2(cyclopropyl), pyridinyl, chloropyridinyl, or methoxypyridinyl: and Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer. |
Author | GAVAI ASHVINIKUMAR V DELUCCA GEORGE V FINK BRIAN E BALOG JAMES AARON O'MALLEY DANIEL QUESNELLE CLAUDE A HAN WENING W. SHAN |
Author_xml | – fullname: O'MALLEY DANIEL – fullname: BALOG JAMES AARON – fullname: GAVAI ASHVINIKUMAR V – fullname: W. SHAN – fullname: QUESNELLE CLAUDE A – fullname: HAN WENING – fullname: DELUCCA GEORGE V – fullname: FINK BRIAN E |
BookMark | eNrjYmDJy89L5WTQcsspzS_KT8zJrszRNdQx0U1KzavKT8lMrEotyAQpUUjOzy3IL81LKeZhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfHOfoYGJhZGRmbm5o7GxKgBAC2KKwQ |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
ExternalDocumentID | CN104822677A |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_CN104822677A3 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 13:00:59 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_CN104822677A3 |
Notes | Application Number: CN201380060053 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150805&DB=EPODOC&CC=CN&NR=104822677A |
ParticipantIDs | epo_espacenet_CN104822677A |
PublicationCentury | 2000 |
PublicationDate | 20150805 |
PublicationDateYYYYMMDD | 2015-08-05 |
PublicationDate_xml | – month: 08 year: 2015 text: 20150805 day: 05 |
PublicationDecade | 2010 |
PublicationYear | 2015 |
RelatedCompanies | BRISTOL-MYERS SQUIBB COMPANY |
RelatedCompanies_xml | – name: BRISTOL-MYERS SQUIBB COMPANY |
Score | 3.0008516 |
Snippet | Disclosed are compounds of Formula (I): wherein: R2 is phenyl, fluorophenyl, chlorophenyl, trifluorophenyl, methylisoxazolyl, or pyridinyl; R3 is H, CH3,... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | Fluoroalkyl-1,4-benzodiazepinone compounds |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150805&DB=EPODOC&locale=&CC=CN&NR=104822677A |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSQPtd7RMMQUmXtM0XRNT01TdpNTEVF1gVWuZlpwGrGJMQRuFff3MPEJNvCJMI5gYsmB7YcDnhJaDD0cE5qhkYH4vAZfXBYhBLBfw2spi_aRMoFC-vVuIrYsatHcMOtzcwFTNxcnWNcDfxd9ZzdnZ1tlPzS8IdMktsCo0Mzd3ZGZgBTWjQefsu4Y5gXalFCBXKW6CDGwBQNPySoQYmFLzhBk4nWE3rwkzcPhCJ7yBTGjeKxZh0HLLKc0vyk_Mya7M0TXUMQH6Nq8qHxi9VakFmcBOfKoCaHk46JakYlEGRTfXEGcPXaCl8XAfxjv7IdxnLMbAAtIkwaCQZJlskpiUamGUbGJhYmySlGhknmRpap6aZJAKagmlSTJI4TZHCp-kNAMXKLTAK9lMZRhYSopKU2WBtWtJkhw4WABqxX5T |
link.rule.ids | 230,309,786,891,25594,76903 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSQPtd7RMMQUmXtM0XRNT01TdpNTEVF1gVWuZlpwGrGJMQRuFff3MPEJNvCJMI5gYsmB7YcDnhJaDD0cE5qhkYH4vAZfXBYhBLBfw2spi_aRMoFC-vVuIrYsatHcMOtzcwFTNxcnWNcDfxd9ZzdnZ1tlPzS8IdMktsCo0Mzd3ZGZgNQd2CcFdpTAn0K6UAuQqxU2QgS0AaFpeiRADU2qeMAOnM-zmNWEGDl_ohDeQCc17xSIMWm45pflF-Yk52ZU5uoY6JkDf5lXlA6O3KrUgE9iJT1UALQ8H3ZJULMqg6OYa4uyhC7Q0Hu7DeGc_hPuMxRhYQJokGBSSLJNNEpNSLYySTSxMjE2SEo3MkyxNzVOTDFJBLaE0SQYp3OZI4ZOUZ-D0CPH1iffx9POWZuAChRx4VZupDANLSVFpqiywpi1JkgMHEQB3o4E9 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Fluoroalkyl-1%2C4-benzodiazepinone+compounds&rft.inventor=O%27MALLEY+DANIEL&rft.inventor=BALOG+JAMES+AARON&rft.inventor=GAVAI+ASHVINIKUMAR+V&rft.inventor=W.+SHAN&rft.inventor=QUESNELLE+CLAUDE+A&rft.inventor=HAN+WENING&rft.inventor=DELUCCA+GEORGE+V&rft.inventor=FINK+BRIAN+E&rft.date=2015-08-05&rft.externalDBID=A&rft.externalDocID=CN104822677A |