Antigen used for immunodetection of tuberculosis infected T cell and application thereof

The invention provides an antigen composition used for immunodetection of a tuberculosis infected cell. The antigen composition comprises a mycobacterium tuberculosis Rv3873 antigen and/or antigen epitope peptides derived from the antigen. In an optimized embodiment, the antigen composition comprise...

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Bibliographic Details
Main Authors WAN KANGLIN, LIU HAICAN, JI SHAOYOU, LI MACHAO, JIANG YI
Format Patent
LanguageEnglish
Published 20.05.2015
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:The invention provides an antigen composition used for immunodetection of a tuberculosis infected cell. The antigen composition comprises a mycobacterium tuberculosis Rv3873 antigen and/or antigen epitope peptides derived from the antigen. In an optimized embodiment, the antigen composition comprises all the antigen epitope peptides contained in the mycobacterium tuberculosis Rv3873 antigen. The invention also provides an application of the antigen composition to preparation of detection reagents used for detecting specific T cell immune response caused by tuberculosis infection in vitro. After lymphocytes of human or animals are stimulated by the antigen composition, cell factors secreted by a tuberculosis specific T cell are detected.
Bibliography:Application Number: CN201510037101