Azilsartan tetrahydrofuran solvate and preparation method thereof

• Main Authors: ZHANG XINI, LIAO WENJING, GUO XIAOWEN, HUANG LUNING
• Format: Patent
• Language: English
• Published: 29.04.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention provides an azilsartan solvate and a preparation method thereof. The azilsartan solvate is suitable to be used as a drug or used as an intermediate preparing the drug azilsartan ester for treating hypertension. The X-ray powder diffractogram of the azilsartan solvate has characteristic peaks at 7.5+/-0.2, 18.9+/-0.2, 21.2+/-0.2, 22.1+/-0.2, 22.7+/-0.2, 23.2+/-0.2 and 25.0+/-0.2. The preparation method of the solvate comprises the following steps: mixing azilsartan and tetrahydrofuran, and heating to completely or partially dissolve the azilsartan; and cooling to crystallize, and filtering to recover the precipitate, thereby obtaining the target product. The azilsartan solvate has the characteristics of high separation tendency, high stability, no hydroscopic property and the like, and is solvate. The preparation method is simple and convenient, and is suitable for industrial production.