2h-imidazol-4-amine compounds and use thereof as bace inhibitors

• Main Authors: KOLMODIN KARIN, SOEDERMAN PETER, SANDBERG LARS, CSJERNYIK GABOR, SWAHN BRITT-MARIE, KARLSTROEM SOFIA, OEHBERG LISELOTTE
• Format: Patent
• Language: English
• Published: 04.03.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to 2H-imidazol-4-amine compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of the compounds for treating Alphabeta-related pathologies such as Down's syndrome, beta-amyloid angiopathy, Alzheimer's disease, memory lo...