2h-imidazol-4-amine compounds and use thereof as bace inhibitors

• Main Authors: KOLMODIN KARIN, SOEDERMAN PETER, SANDBERG LARS, CSJERNYIK GABOR, SWAHN BRITT-MARIE, KARLSTROEM SOFIA, OEHBERG LISELOTTE
• Format: Patent
• Language: English
• Published: 04.03.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to 2H-imidazol-4-amine compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of the compounds for treating Alphabeta-related pathologies such as Down's syndrome, beta-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration methods of therapy, and pharmaceutical compositions containing such compounds. In a formula (I), A is -O- or -CH2-, and n is 0 or 1.