Benzoic amide compound as well as preparation method and application thereof

The invention relates to a preparation method of substances related to bulk drug roflumilast, namely two benzoic amide compounds N-(3,5-dichloropyridine-4-yl)-3,4-di(difluoro methoxyl) benzoic amide (IA) and N-(3,5-dichloropyridine-4-yl)-3-difluoro methoxyl-4-cyprolidol methoxyl benzoic amide (IB),...

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Bibliographic Details
Main Authors LIU YOUXIAN, ZHONG AIJUN, YUAN XIUJU, WANG XUEJIAO, YAO LIANGYUAN
Format Patent
LanguageChinese
English
Published 18.09.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
TESTING
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Summary:The invention relates to a preparation method of substances related to bulk drug roflumilast, namely two benzoic amide compounds N-(3,5-dichloropyridine-4-yl)-3,4-di(difluoro methoxyl) benzoic amide (IA) and N-(3,5-dichloropyridine-4-yl)-3-difluoro methoxyl-4-cyprolidol methoxyl benzoic amide (IB), application of the substances in the aspects of controlling or providing mass of roflumilast products, and a method for controlling the mass of roflumilast in a roflumilast preparation technology.
Bibliography:Application Number: CN201310233213