Crystalline d-isoglutamyl-d-tryptophan and the mono ammonium slat of d-isoglutamyl-d-tryptophan

A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D- isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D- tryptophan. A process is also provided for the preparation...

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Main Authors LEUNG-TOUNG REGIS, YU LILY, TAM TIM FAT, ZHAO YANQING, N ZEMBA BLAISE, WANG YINGSHENG
Format Patent
LanguageChinese
English
Published 11.09.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Abstract A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D- isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D- tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D- isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1 :1) is a stable pharmaceutical solid.
AbstractList A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D- isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D- tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D- isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1 :1) is a stable pharmaceutical solid.
Author WANG YINGSHENG
YU LILY
TAM TIM FAT
ZHAO YANQING
LEUNG-TOUNG REGIS
N ZEMBA BLAISE
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– fullname: WANG YINGSHENG
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Snippet A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title Crystalline d-isoglutamyl-d-tryptophan and the mono ammonium slat of d-isoglutamyl-d-tryptophan
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