Modulators of 5-HT receptors and methods of use thereof

The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I), wherein R1,R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined...

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Main Authors WELCH DENNIE S, ZHAO HONGYU, WILSON NOEL S, AKRITOPOULOU-ZANZE IRINI, BRAJE WILFRIED, THOMPSON CHRISTINA M, TURNER SEAN C, KRUGER ALBERT W, SHEKHAR SHASHANK, LI HUANQIU, ZHANG MIN, RELO ANA-LUCIA, GASIECKI ALAN F, DJURIC STEVAN W, GANDARILLA JORGE
Format Patent
LanguageChinese
English
Published 03.10.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I), wherein R1,R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
AbstractList The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I), wherein R1,R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Author BRAJE WILFRIED
RELO ANA-LUCIA
KRUGER ALBERT W
DJURIC STEVAN W
AKRITOPOULOU-ZANZE IRINI
ZHAO HONGYU
WELCH DENNIE S
GANDARILLA JORGE
ZHANG MIN
THOMPSON CHRISTINA M
SHEKHAR SHASHANK
WILSON NOEL S
TURNER SEAN C
LI HUANQIU
GASIECKI ALAN F
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– fullname: RELO ANA-LUCIA
– fullname: GASIECKI ALAN F
– fullname: DJURIC STEVAN W
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Snippet The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide,...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Modulators of 5-HT receptors and methods of use thereof
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