Synthetic method of narcotine

The invention belongs to the technical field of medicines, relates to a synthetic method of narcotine and particularly relates to a synthetic method of narcotine by using an intermediate. The method comprises the following steps of: (1) carrying out bromination, hydrolysis, cyclization and condensat...

Full description

Saved in:
Bibliographic Details
Main Authors QIAN WANGKE, MAO YONGJUN, LU XUEHUA, SONG SHUAI, NA LUXIN, SUN LIANG, CHENG MAOSHENG, ZHAO DONGMEI
Format Patent
LanguageChinese
English
Published 05.09.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:The invention belongs to the technical field of medicines, relates to a synthetic method of narcotine and particularly relates to a synthetic method of narcotine by using an intermediate. The method comprises the following steps of: (1) carrying out bromination, hydrolysis, cyclization and condensation on vanillic aldehyde, and then reducing and salting to obtain 3-methoxyl-4,5-methylendioxyphenylethylamine hydrochloride; (2) carrying out cyclization, hydrolysis and halogenation on 2,3-dimethoxy benzoic acid to obtain 6,7-dimethoxybenzofuranone-3-acyl chloride; and (3) butting the 3-methoxyl-4,5-methylendioxyphenylethylamine hydrochloride with the 6,7-dimethoxybenzofuranone-3-acyl chloride to obtain N-beta-(3-methoxyl-4,5-methylendioxyphenyl)ethyl-6',7'-dimethoxybenzofuranone-3-acyl chloride, and then carrying out the cyclization, reduction, chiral resolution and methylation to obtain the narcotine. The preparation method disclosed by the invention overcomes the disadvantages of the existing synthetic method
Bibliography:Application Number: CN2011149910