Synthetic method of dimethyl cysteamine hydrochloride

• Main Authors: WANG WEI, MA JINGWU, MA JIANGUO, LI MING, ZHAI TING, WANG YONGHENG
• Format: Patent
• Language: Chinese; English
• Published: 02.05.2012
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a synthetic method of dimethyl cysteamine hydrochloride. The method comprises the following steps of: synthesizing 5,5-dimethyl-2-isopropyl thiazoline by taking isobutylaldehyde, element sulfur, ammonia gas and triethylamine as raw materials; reducing the 5,5-dimethyl-2-isopropyl thiazoline into 5,5-dimethyl-2-isopropyl thiazolidine under the actions of sodium borohydride and acid; and reacting the 5,5-dimethyl-2-isopropyl thiazolidine and phenyl hydrazine under the air insulating situation to obtain dimethyl cysteamine hydrochloride. The method has the advantages of readily-available reaction raw materials, easiness for operating the reaction process, low requirement on the reaction equipment, relatively mild reaction conditions, feeding of the product of every step of reaction into a next step reaction after refining and purifying, high yield and high purity, and the purity of the finally-obtained dimethyl cysteamine hydrochloride is close to 100 percent.