Quinuclidine derivatives as muscarinic M3 receptor antagonists

The invention provides named compounds of formula ( I ), wherein R4 is a N-sustituted quinuclidine ( I ) pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions. Their use in therapy for' the treatment of conditions mediated by M3 muscarinic recep...

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Main Authors BULL RICHARD JAMES, SKIDMORE ELIZABETH ANNE, METE ANTONIO, MATHER ANDREW NIGEL, FORD RHONAN LEE
Format Patent
LanguageChinese
English
Published 08.06.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The invention provides named compounds of formula ( I ), wherein R4 is a N-sustituted quinuclidine ( I ) pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions. Their use in therapy for' the treatment of conditions mediated by M3 muscarinic receptors, such as chronic obstructive pulmonary disease is also disclosed.
AbstractList The invention provides named compounds of formula ( I ), wherein R4 is a N-sustituted quinuclidine ( I ) pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions. Their use in therapy for' the treatment of conditions mediated by M3 muscarinic receptors, such as chronic obstructive pulmonary disease is also disclosed.
Author MATHER ANDREW NIGEL
METE ANTONIO
SKIDMORE ELIZABETH ANNE
BULL RICHARD JAMES
FORD RHONAN LEE
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ASTRAZENECA AB
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Snippet The invention provides named compounds of formula ( I ), wherein R4 is a N-sustituted quinuclidine ( I ) pharmaceutical compositions containing them and a...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Quinuclidine derivatives as muscarinic M3 receptor antagonists
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