Vaccine adjuvant of swine mycoplasmal pneumonia live vaccine, and preparation method and application thereof

• Main Authors: XIONG QIYAN, ZHANG DAOHUA, LIU MAOJUN, SHAO GUOQING, FENG ZHIXIN
• Format: Patent
• Language: Chinese; English
• Published: 26.01.2011
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a vaccine adjuvant of swine mycoplasmal pneumonia live vaccine, which is mainly prepared from an ISCOM substrate, levamisole, traditional Chinese herbal polysaccharide and phosphate buffer. Each ml of adjuvant contains 0.1 to 2mg of Quil A in the ISCOM substrate, 2 to 10mg of levamisole, 20 to 100mg of traditional Chinese herbal polysaccharide and the balance of phosphate buffer. The combination of the ISCOM substrate, the levamisole and the traditional Chinese herbal polysaccharide can well make the best of respective advantages and complement each other, so that the adjuvant can strengthen the immune stimulating ability of the swine mycoplasmal pneumonia live vaccine and strengthen the immune effect of the vaccine, and has the advantages of simple and convenient preparation method, stable performance, convenient mass production and the like. When the vaccine adjuvant is applied, intramuscular injection immunization can be performed by blending a proper proportion of swine mycoplasmal