Oral insulin containing protease inhibitor

• Main Authors: CHEN YUJUN, GAO JING, AN WENJING, LI HUICHENG, LENG GUOQING, ZHAO HUANAN, HUANG YAN, ZHANG YUHUA, LI JINHUA, WANG ZHONG, LIU HEYU, SU HONGJIAN
• Format: Patent
• Language: Chinese; English
• Published: 20.10.2010
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses oral insulin, the preparation relates to a polymer chemistry technology, and the technology can be applied to the synthesis of polymersomes gel components in the oral medication approach of insulin. The invention provides a preparation method for forming polymersomes gel by polymerizing protease inhibitor- ovomucoid (glycoprotein extracted from duck eggs), acrylamide and the like, a preparation method of the preparation thereof and application thereof in reducing animal hyperglycemia. The ovomucoid is used for protecting oral insulin for the first time, and the preparation of the polymersomes gel can be used for curing diabetes. The bioavailability of the preparation reaches above 20 percent of the same dose of subcutaneous injection insulin, and the preparation has the advantage of convenient medication, prevents the defects of injection pain and poor tolerance, and has very high use value.