Method of synthesizing tertiary aromatic amine through coupling reaction of aryl bromide and secondary aromatic amine under catalysis of nickel

• Main Authors: YANG LIANMING, CAO XINGBO, GAO CAIYAN, CHEN CHEN
• Format: Patent
• Language: Chinese; English
• Published: 24.03.2010
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a method of synthesizing tertiary aromatic amine compound, in particular to a method of synthesizing tertiary aromatic amine through the coupling reaction of aryl bromide andsecondary aromatic amine under the catalysis of nickel, which has the characteristics of moderate reaction condition, low cost, high yield, good reproducibility and scale operation. Nickelous compoundwhich is cheap, easy to obtain and stable in air is used as catalyst; alkyl Grignard reagent or sodium hydride is used as both alkali and reductant; and the coupling reaction of aryl bromide and secondary aromatic amine can be realized under the moderate reaction temperature of 90-95 DEG C. The method of synthesizing the tertiary aromatic amine compound overcomes the defects that the coupling reaction of the aryl bromide and the secondary aromatic amine under the catalysis of copper needs high temperature and long time, generates much side reaction and is hard to process subsequently and alsoovercomes the defects that