Method for determining the amount of conjugated taxane in polyglut acid-taxane conjugates

• Main Authors: HOVDA KEITH, FAZIONI STEFANO, SIVIERO LUIGI, MCKENNON MARC, SPOONEMORE HOLLY, LIVI VALERIA
• Format: Patent
• Language: Chinese; English
• Published: 24.09.2014
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention relates to a method for determining the amount of conjugated taxane, in particular paclitaxel, in a PGA-taxane conjugate said method comprising: a) reacting the PGA-taxane conjugate with a compound formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R 1 R 2 N-NH 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I) wherein R 1 and R 2 are as de...