Process for establishing anti-parkinson animal model

• Main Authors: HUANG FANG, HE KUNYAN, SUN FENGYAN, YU MEI, BIAN MINJUAN
• Format: Patent
• Language: Chinese; English
• Published: 22.10.2008
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TRAPPING; VINEGAR; WINE

The invention relates to the neurology in biomedicine, geratology and transgenic technology field, in particular providing a method for building an antiparkinsonian animal model and the antiparkinsonian animal model. The method is as follows: an exogenetic Parkin-Flag expression cassette is transferred into a genome of an animal and contains (a) starters of bandicoot enolase, (b) one part of -globin genes and Parkin-Flag or Parkin-Flag, and (c) mini-genes of human growth hormone or SV40 polyadenylation tailing signals. The invention also provides use of the antiparkinsonian animal model obtained in filtering gene targets for curing parkinsonism.