Process for establishing anti-parkinson animal model

The invention relates to the neurology in biomedicine, geratology and transgenic technology field, in particular providing a method for building an antiparkinsonian animal model and the antiparkinsonian animal model. The method is as follows: an exogenetic Parkin-Flag expression cassette is transfer...

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Bibliographic Details
Main Authors HUANG FANG, HE KUNYAN, SUN FENGYAN, YU MEI, BIAN MINJUAN
Format Patent
LanguageChinese
English
Published 22.10.2008
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BEER
BIOCHEMISTRY
CARE OF BIRDS, FISHES, INSECTS
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NEW BREEDS OF ANIMALS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
SPIRITS
TRAPPING
VINEGAR
WINE
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Summary:The invention relates to the neurology in biomedicine, geratology and transgenic technology field, in particular providing a method for building an antiparkinsonian animal model and the antiparkinsonian animal model. The method is as follows: an exogenetic Parkin-Flag expression cassette is transferred into a genome of an animal and contains (a) starters of bandicoot enolase, (b) one part of -globin genes and Parkin-Flag or Parkin-Flag, and (c) mini-genes of human growth hormone or SV40 polyadenylation tailing signals. The invention also provides use of the antiparkinsonian animal model obtained in filtering gene targets for curing parkinsonism.
Bibliography:Application Number: CN2008190864