Oral dosage form safeguarded against abuse containing (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol

The invention relates to an oral dosage form, which is safeguarded against abuse and which has a controlled release of (1R, 2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol for a once daily administering. The invention is characterized in that the oral dosage form comprises the active ingredie...

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Main Author BARTHOLOMAUS JOHANNES,KUGELMANN HEINRICH
Format Patent
LanguageEnglish
Published 22.08.2007
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Abstract The invention relates to an oral dosage form, which is safeguarded against abuse and which has a controlled release of (1R, 2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol for a once daily administering. The invention is characterized in that the oral dosage form comprises the active ingredient and/or one or more pharmaceutically acceptable compounds (A) thereof, at least one synthetic and/or natural polymer (C), retarding adjuvants, optionally comprises additional physiologically compatible adjuvants (B), and optionally comprises a wax (D). The oral dosage form has a breaking resistance of at least 500 N, preferably at least 750 N. The dosage form contains at least one of the following abuse-preventing constituents (a)-(f); (a) at least one substance that irritates the nasal and/or pharyngeal cavity; (b) at least one viscosity-increasing agent; (c) at least one antagonist for the active ingredient having an abuse potential; (d) at least one emetic; (e) at least one colorant serving as an aversive agent, and; (f) at least one bitter substance.
AbstractList The invention relates to an oral dosage form, which is safeguarded against abuse and which has a controlled release of (1R, 2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol for a once daily administering. The invention is characterized in that the oral dosage form comprises the active ingredient and/or one or more pharmaceutically acceptable compounds (A) thereof, at least one synthetic and/or natural polymer (C), retarding adjuvants, optionally comprises additional physiologically compatible adjuvants (B), and optionally comprises a wax (D). The oral dosage form has a breaking resistance of at least 500 N, preferably at least 750 N. The dosage form contains at least one of the following abuse-preventing constituents (a)-(f); (a) at least one substance that irritates the nasal and/or pharyngeal cavity; (b) at least one viscosity-increasing agent; (c) at least one antagonist for the active ingredient having an abuse potential; (d) at least one emetic; (e) at least one colorant serving as an aversive agent, and; (f) at least one bitter substance.
Author BARTHOLOMAUS JOHANNES,KUGELMANN HEINRICH
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Snippet The invention relates to an oral dosage form, which is safeguarded against abuse and which has a controlled release of (1R,...
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HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title Oral dosage form safeguarded against abuse containing (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
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