SELS D'ISOTHIURONIUM, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

• Main Authors: VERTESI, CSABA, GUCZOGHY, LAJOS, MOLNAR, ATTILA
• Format: Patent
• Language: French
• Published: 30.06.1988
• Edition: 4
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

PCT No. PCT/HU85/00022 Sec. 371 Date Nov. 25, 1985 Sec. 102(e) Date Nov. 25, 1985 PCT Filed Apr. 2, 1985 PCT Pub. No. WO85/04399 PCT Pub. Date Oct. 10, 1985.According to the present invention there are provided isothiuronium salts of the general Formula I (I) wherein R1 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, aralkyl or aryl, the said groups being optionally substituted by one or more hydroxy, mercapto and/or halogen; R2 stands for hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or C3-6 cycloalkyl; X represents an organic or inorganic anion/. The compounds and salts of the present invention can be prepared by reacting a compound of the general Formula II (II) with an agent capable of introducing a R1 group. The compounds of the general Formula I exhibit antitumor and immunostimulant effect and are useful in therapy.