Verfahren zur Herstellung neuer 5-Aryl-, bzw. Heteroaryl-Benzotetrahydrodiazepin-24-dione

• Main Authors: WEBER,KARL-HEINZ,DR, MERZ,HERBERT,DR, ZEILE,KARL
• Format: Patent
• Language: German
• Published: 31.12.1971
• Edition: 1
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

1,274,029. Psychosedative &c compositions. BOEHRINGER INGELHEIM G.m.b.H. 14 July, 1969 [12 July, 1968 (2)], No. 35374/69. Heading A5B. [Also in Division C2] Pharmaceutical compositions comprise a compound of the formula: (R 1 =C 1-4 alkyl optionally substituted by halogen, OH, alkoxy, acyloxy, C 2-4 dialkylamino or 5-6 membered N-containing heterocyclic ring linked via the N atom, unsubstituted or mono- or di-methyl or monochloro substituted allyl, cyclohexyl, C 4-7 cycloalkylmethyl or cycloalkenylmethyl, unsubstituted or mono- or di-methyl, -methoxy or -chloro substituted aryl, C 7-8 phenylalkyl, heteroaryl; R 2 =H, Me; R 3 =naphthyl, pyrimidyl, pyrazinyl, pyridazinyl, thienyl, furyl, unsubstituted or methyl or halogen substituted pyridyl or group of the formula: wherein R 5 =H, halogen, Me, Et, MeOCF 3 , CN, NO 2 , C 2-3 acyl or alkoxycarbonyl; R 6 = H, halogen, Me, Et, MeO; R 4 =H, halogen, Me, MeO, CF 3 , CN, C 2-3 acyl or alkoxycarbonyl), with or without other active ingredients (e.g. spasmolytics and/or psychopharmaceuticals), in association with a carrier. The primary active ingredients are psychosedatives and anticonvulsants. Reference has been directed by the Comptroller to Specification 1,210,809; 1,210,810; 1,214,662; 1,214,663 and 1,217,217.