Verfahren zur Herstellung von d-Phenylessigsäuren

Novel alcohols of the general formulae <FORM:1109190/C2/1> and <FORM:1109190/C2/2> (wherein R00 represents a methylene or ethylidene radical, R** a C1- 5 alkyl radical, Rp a cyclohexyl, cyclopentyl or C1- 5 alkyl radical and Rm a halogen atom or a C1- 5 alkoxy or alkylthio trihalomethyl,...

Full description

Saved in:
Bibliographic Details
Main Authors VANCE RUYLE,WILLIAM, PETER,JR. DORN,CONRAD, SHEN,TSUNG-YIN
Format Patent
LanguageGerman
Published 15.01.1970
Edition1
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:Novel alcohols of the general formulae <FORM:1109190/C2/1> and <FORM:1109190/C2/2> (wherein R00 represents a methylene or ethylidene radical, R** a C1- 5 alkyl radical, Rp a cyclohexyl, cyclopentyl or C1- 5 alkyl radical and Rm a halogen atom or a C1- 5 alkoxy or alkylthio trihalomethyl, SH, NH2, di-(C1- 5 alkyl)-amino, CN, ND2, CONH2, C1- 6 alkanoylamino, C1- 4 alkylsulphonyl, di-(C1- 5 alkyl)-sulphamoyl or OH radical, and x is 1 or 2, with the provisos that at least one Rm substituent is in one of the m-positions relative to the side chain, and that there is at most one trihalomethyl substituent which must be in such m-position) are prepared by reducing the corresponding carboxylic acids (containing -COOH in place of -CH2OH), preferably by means of an alkali or alkaline-earth metal aluminium hydride. The alcohols may be converted to their alkyl or ethoxyethyl ethers by the action of alkylating or ethoxyethylating agents. Pharmaceutical compositions, having anti-inflammatory activity, contain the novel alcohols and ethers as active ingredients.
Bibliography:Application Number: CH19650008269