PEPTIDE VACCINE
The present invention provides one or more immunogenic peptides derived from a PRMT5-E2F1 axis regulated long non-coding RNA gene or a derivative thereof; a pharmaceutical composition comprising one or more of said peptides; a vaccine comprising one or more of said peptides and their use in therapy,...
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Format | Patent |
Language | English French |
Published |
01.06.2023
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Abstract | The present invention provides one or more immunogenic peptides derived from a PRMT5-E2F1 axis regulated long non-coding RNA gene or a derivative thereof; a pharmaceutical composition comprising one or more of said peptides; a vaccine comprising one or more of said peptides and their use in therapy, including a method for eliciting an immune response in a mammalian subject by administration of an agent capable of presenting the peptides to the host. The invention also relates to the use of a PRMT5 inhibitor for use in treating cancer by stimulating host immunity.
La présente invention concerne un ou plusieurs peptides immunogènes dérivés d'un gène d'ARN long non codant régulé par l'axe PRMT5-E2F1 ou d'un dérivé de celui-ci ; une composition pharmaceutique comprenant un ou plusieurs desdits peptides ; un vaccin comprenant un ou plusieurs desdits peptides et leur utilisation en thérapie, y compris dans une méthode pour déclencher une réponse immunitaire chez un sujet mammifère par administration d'un agent capable de présenter les peptides à l'hôte. L'invention concerne également l'utilisation d'un inhibiteur de PRMT5 pour le traitement du cancer par stimulation de l'immunité de l'hôte. |
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AbstractList | The present invention provides one or more immunogenic peptides derived from a PRMT5-E2F1 axis regulated long non-coding RNA gene or a derivative thereof; a pharmaceutical composition comprising one or more of said peptides; a vaccine comprising one or more of said peptides and their use in therapy, including a method for eliciting an immune response in a mammalian subject by administration of an agent capable of presenting the peptides to the host. The invention also relates to the use of a PRMT5 inhibitor for use in treating cancer by stimulating host immunity.
La présente invention concerne un ou plusieurs peptides immunogènes dérivés d'un gène d'ARN long non codant régulé par l'axe PRMT5-E2F1 ou d'un dérivé de celui-ci ; une composition pharmaceutique comprenant un ou plusieurs desdits peptides ; un vaccin comprenant un ou plusieurs desdits peptides et leur utilisation en thérapie, y compris dans une méthode pour déclencher une réponse immunitaire chez un sujet mammifère par administration d'un agent capable de présenter les peptides à l'hôte. L'invention concerne également l'utilisation d'un inhibiteur de PRMT5 pour le traitement du cancer par stimulation de l'immunité de l'hôte. |
Author | LA THANGUE, NICHOLAS BARCZAK, WOJCIECH CARR, SIMON MARK |
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Snippet | The present invention provides one or more immunogenic peptides derived from a PRMT5-E2F1 axis regulated long non-coding RNA gene or a derivative thereof; a... |
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Title | PEPTIDE VACCINE |
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