PYRIDINYL DERIVATIVES AS SODIUM CHANNEL ACTIVATORS

The present disclosure is directed to compounds of formula (I): wherein X, Y, Z, R1, R2a, R2b, R3, and L are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositi...

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Bibliographic Details
Main Authors BURFORD, KRISTEN, CLEMENT, HELEN, CHARIFSON, PAUL, LOFSTRAND, VERNER, CLARK, MICHAEL, KIM, JUNG YUN
Format Patent
LanguageEnglish
French
Published 30.03.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure is directed to compounds of formula (I): wherein X, Y, Z, R1, R2a, R2b, R3, and L are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy. La présente divulgation a pour objet des composés de formule (I) : X, Y, Z, R1, R2a, R2b, R3 et L étant tels que présentés dans la description, utilisés en tant que stéréoisomères, énantiomères ou tautomères de ceux-ci ou leurs mélanges; ou leurs sels, solvates ou promédicaments pharmaceutiquement acceptables, et des compositions pharmaceutiques comprenant les composés de formule (I), tels que présentés dans la description, qui sont utiles en tant que modulateurs de canaux sodiques activés par tension et sont par conséquent utiles dans le traitement de troubles épileptiques tels que l'épilepsie.
Bibliography:Application Number: CA20223232237