PRODUCTION OF ENGINEERED T CELLS FROM STEM CELLS

• Main Authors: WIEZOREK, JEFFREY SCOTT, GOV, LANNY, ALLEN, SEAN, SMITHAKE, WANG, XI
• Format: Patent
• Language: English; French
• Published: 17.11.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

This disclosure provides methods for producing T cells with shortened ex vivo manufacturing time. In particular, this disclosure involves the production of T cells from hematopoietic stem cells with the proviso that the process does not involve subsequent in vitro steps of activation and/or expansion of the T cells. La présente divulgation concerne des procédés de production de lymphocytes T avec un temps de fabrication ex vivo raccourci. En particulier, la présente divulgation concerne la production de lymphocytes T à partir de cellules souches hématopoïétiques à condition que le procédé ne mette pas en jeu des étapes ultérieures in vitro d'activation et/ou d'expansion des lymphocytes T.