STAPHYLOCOCCUS AUREUS VACCINE COMPOSITIONS
The present disclosure relates to immunogenic compositions for inducing an immune response in a subject for the treatment and/or prevention of a Staphylococcus aureus infection. The immunogenic compositions disclosed herein comprise a S. aureus protein A (SpA) polypeptide and a S. aureus Leukocidin...
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| Format | Patent |
| Language | English French |
| Published |
06.10.2022
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| Subjects | |
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| Abstract | The present disclosure relates to immunogenic compositions for inducing an immune response in a subject for the treatment and/or prevention of a Staphylococcus aureus infection. The immunogenic compositions disclosed herein comprise a S. aureus protein A (SpA) polypeptide and a S. aureus Leukocidin A (LukA) and/or Leukocidin B (LukB) variant polypeptide. The present disclosure further relates to methods of generating an immune response against S. aureus in a subject that involve administering the disclosed immunogenic compositions.
La présente divulgation concerne des compositions immunogènes permettant d'induire une réponse immunitaire chez un sujet pour le traitement et/ou la prévention d'une infection à Staphylococcus aureus. Les compositions immunogènes de la divulgation comprennent un polypeptide de protéine A de S. aureus (SpA) et un polypeptide variant leucocidine A (LukA) et/ou leucocidine B (LukB) de S. aureus. La présente divulgation concerne en outre des méthodes de génération d'une réponse immunitaire contre S. aureus chez un sujet qui impliquent l'administration des compositions immunogènes divulguées. |
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| AbstractList | The present disclosure relates to immunogenic compositions for inducing an immune response in a subject for the treatment and/or prevention of a Staphylococcus aureus infection. The immunogenic compositions disclosed herein comprise a S. aureus protein A (SpA) polypeptide and a S. aureus Leukocidin A (LukA) and/or Leukocidin B (LukB) variant polypeptide. The present disclosure further relates to methods of generating an immune response against S. aureus in a subject that involve administering the disclosed immunogenic compositions.
La présente divulgation concerne des compositions immunogènes permettant d'induire une réponse immunitaire chez un sujet pour le traitement et/ou la prévention d'une infection à Staphylococcus aureus. Les compositions immunogènes de la divulgation comprennent un polypeptide de protéine A de S. aureus (SpA) et un polypeptide variant leucocidine A (LukA) et/ou leucocidine B (LukB) de S. aureus. La présente divulgation concerne en outre des méthodes de génération d'une réponse immunitaire contre S. aureus chez un sujet qui impliquent l'administration des compositions immunogènes divulguées. |
| Author | BUCKLEY, PETER T KONSTANTINOV, SERGEY SOMANI, SANDEEP TORRES, VICTOR J POOLMAN, JAN THEUNIS MORROW, BRIAN GEURTSEN, JEROEN LUO, JINQUAN |
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| Snippet | The present disclosure relates to immunogenic compositions for inducing an immune response in a subject for the treatment and/or prevention of a Staphylococcus... |
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| Title | STAPHYLOCOCCUS AUREUS VACCINE COMPOSITIONS |
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