4-AMINOQUINAZOLINE COMPOUND
[Problem] To provide compounds that are useful as active ingredients of pharmaceutical compositions for the treatment of pancreatic cancer. [Solution] The present inventors studied compounds that are useful as active ingredients of pharmaceutical compositions for pancreatic cancer treatment, found t...
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| Main Authors | , , , , , , , , , , , , , |
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| Format | Patent |
| Language | English French |
| Published |
18.08.2022
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| Subjects | |
| Online Access | Get full text |
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| Abstract | [Problem] To provide compounds that are useful as active ingredients of pharmaceutical compositions for the treatment of pancreatic cancer. [Solution] The present inventors studied compounds that are useful as active ingredients of pharmaceutical compositions for pancreatic cancer treatment, found that 4-aminoquinazoline compounds have exceptional G12D mutant KRAS inhibitory activity and can be used as therapeutic agents for pancreatic cancer, and completed the present invention. The 4-aminoquinazoline compound or salts thereof according to the present invention can be used as therapeutic agents for pancreatic cancer.
Le problème décrit par la présente invention est de fournir des composés qui sont utiles en tant que principes actifs de compositions pharmaceutiques pour le traitement du cancer du pancréas. À cet effet, les présents inventeurs ont étudié des composés qui sont utiles en tant que principes actifs de compositions pharmaceutiques pour le traitement du cancer du pancréas, et ont trouvé que les composés de 4-aminoquinazoline ont une activité inhibitrice de KRAS à mutation G12D exceptionnelle et peuvent être utilisés en tant qu'agents thérapeutiques pour le cancer du pancréas, et complétés par la présente invention. Le composé de 4-aminoquinazoline ou les sels de celui-ci selon la présente invention peuvent être utilisés en tant qu'agents thérapeutiques pour le cancer du pancréas. |
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| AbstractList | [Problem] To provide compounds that are useful as active ingredients of pharmaceutical compositions for the treatment of pancreatic cancer. [Solution] The present inventors studied compounds that are useful as active ingredients of pharmaceutical compositions for pancreatic cancer treatment, found that 4-aminoquinazoline compounds have exceptional G12D mutant KRAS inhibitory activity and can be used as therapeutic agents for pancreatic cancer, and completed the present invention. The 4-aminoquinazoline compound or salts thereof according to the present invention can be used as therapeutic agents for pancreatic cancer.
Le problème décrit par la présente invention est de fournir des composés qui sont utiles en tant que principes actifs de compositions pharmaceutiques pour le traitement du cancer du pancréas. À cet effet, les présents inventeurs ont étudié des composés qui sont utiles en tant que principes actifs de compositions pharmaceutiques pour le traitement du cancer du pancréas, et ont trouvé que les composés de 4-aminoquinazoline ont une activité inhibitrice de KRAS à mutation G12D exceptionnelle et peuvent être utilisés en tant qu'agents thérapeutiques pour le cancer du pancréas, et complétés par la présente invention. Le composé de 4-aminoquinazoline ou les sels de celui-ci selon la présente invention peuvent être utilisés en tant qu'agents thérapeutiques pour le cancer du pancréas. |
| Author | NAGASHIMA, TAKEYUKI OKUMURA, MITSUAKI FUKUDOME, HIROKI KURAMOTO, KAZUYUKI KURIWAKI, IKUMI KAWAGUCHI, KENICHI MORIKAWA, TAKAHIRO IMADA, SUNAO KAWAMINAMI, EIJI SATO, RYO IMAIZUMI, TOMOYOSHI ISHIOKA, HIROKI HAMAGUCHI, HISAO SEKI, YOHEI |
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| Snippet | [Problem] To provide compounds that are useful as active ingredients of pharmaceutical compositions for the treatment of pancreatic cancer. [Solution] The... |
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| Title | 4-AMINOQUINAZOLINE COMPOUND |
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