3H,4H,5H,6H,7H-PYRIMIDO[4,5-B][1,4]OXAZINE-4,6-DIONE DERIVATIVES AS TRPA1 INHIBITORS
The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPAl. Also provided are pharmaceutical c...
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| Main Authors | , |
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| Format | Patent |
| Language | English French |
| Published |
20.10.2022
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPAl. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
La présente invention concerne certains dérivés de 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione qui sont des inhibiteurs de récepteur à potentiel de récepteur transitoire ankyrine 1 (TRPA1), et sont par conséquent utiles pour le traitement de maladies pouvant être traitées par inhibition de TRPAl. L'invention concerne également des compositions pharmaceutiques les contenant, et des procédés de préparation desdits composés. |
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| AbstractList | The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPAl. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
La présente invention concerne certains dérivés de 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione qui sont des inhibiteurs de récepteur à potentiel de récepteur transitoire ankyrine 1 (TRPA1), et sont par conséquent utiles pour le traitement de maladies pouvant être traitées par inhibition de TRPAl. L'invention concerne également des compositions pharmaceutiques les contenant, et des procédés de préparation desdits composés. |
| Author | FLECK, MARTIN THOMAS BINDER, FLORIAN PAUL CHRISTIAN |
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| DocumentTitleAlternate | DERIVES DE 3H,4H,5H,6H,7H-PYRIMIDO[4,5-B][1,4]OXAZINE-4,6-DIONE EN TANT QU'INHIBITEURS DE TRPA1 |
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| Snippet | The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5- b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential... |
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| Title | 3H,4H,5H,6H,7H-PYRIMIDO[4,5-B][1,4]OXAZINE-4,6-DIONE DERIVATIVES AS TRPA1 INHIBITORS |
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