IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATED CAPSULAR SACCHARIDE ANTIGENS AND USES THEREOF

• Main Authors: SACKETT, KELLY JEFFREY, DUTTA, KAUSHIK, BROWN, PAUL WAYNE, LOTVIN, JASON ARNOLD
• Format: Patent
• Language: English; French
• Published: 19.05.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions. La présente invention concerne de nouvelles compositions immunogènes comprenant des antigènes (glycoconjugués) saccharidiques capsulaires de Streptococcus pneumoniae conjugués, des kits comprenant lesdites compositions immunogènes et leurs utilisations. Les compositions immunogènes de la présente invention comprennent généralement au moins un glycoconjugué d'un sérotype de S. pneumoniae que l'on ne trouve pas dans PREVNAR®, SYNFLORIX® et/ou PREVNAR 13®. L'invention concerne également la vaccination de sujets humains, en particulier des nourrissons et des personnes âgées, contre des infections pneumococciques à l'aide desdites nouvelles compositions immunogènes.