METHOD OF SAFE ADMINISTRATION OF ANTI-TAU ANTIBODY

• Main Authors: HENLEY, DAVID, LI, LINGJUE, NANDY, PARTHA, RUIXO, CARLOS PEREZ
• Format: Patent
• Language: English; French
• Published: 05.05.2022
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

Methods are described for safely administering to a subject in need thereof an anti-tau antibody that bind to tau, in particular that bind to a phosphorylated epitope on tau. The methods comprise administering a pharmaceutical composition comprising the anti-tau antibody, in which the anti-tau antibody is administered in an amount of about 500 mg to 5000 mg per dose. L'invention concerne des méthodes pour administrer en toute sécurité à un sujet qui en a besoin un anticorps anti-tau qui se lie à tau, en particulier qui se lie à un épitope phosphorylé sur tau. Les méthodes comprennent l'administration d'une composition pharmaceutique comprenant l'anticorps anti-tau, dans laquelle l'anticorps anti-tau est administré en une quantité d'environ 500 mg à 5 000 mg par dose.