BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF

• Main Authors: WANG, WENYUE, HONJO, ERIKO, EVANS, CHRIS, KATOH, NAOTO, KURIWAKI, IKUMI, YAMASAKI, MAKOTO, LU, PU-PING, COLLIBEE, SCOTT, TSUCHIYA, KAZUYUKI, KUROSAKI, TOSHIO, YAMAKI, SUSUMU, SEKIOKA, RYUICHI, KOIZUMI, YUKA, MORGAN, BRADLEY P, MAKINO, TAKUYA
• Format: Patent
• Language: English; French
• Published: 12.05.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compoun...