PILRA ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human PILRA and compositions comprising such antibodies or antigen-binding fragments thereof. In a particular aspect, the antibodies or antigen-binding fragments thereof that specifically bind...
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Format | Patent |
Language | English French |
Published |
26.08.2021
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Abstract | The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human PILRA and compositions comprising such antibodies or antigen-binding fragments thereof. In a particular aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human PILRA block binding of PILRA to ligand and/or decrease cell surface PILRA. In further aspects, the antibodies or antigen-binding fragments can be used to treat diseases or conditions associated with myeloid cell dysfunction.
La présente invention concerne des anticorps et des fragments de liaison à l'antigène associés qui se lient spécifiquement à PILRA humain ainsi que des compositions comprenant de tels anticorps ou fragments de liaison à l'antigène associés. Dans un aspect particulier, les anticorps ou fragments de liaison à l'antigène de ceux-ci qui se lient spécifiquement à PILRA humain, bloquent la liaison de PILRA à un ligand et/ou diminuent PILRA sur la surface cellulaire. Dans d'autres aspects, les anticorps ou fragments de liaison à l'antigène peuvent être utilisés pour traiter des maladies ou des affections associées à un dysfonctionnement des cellules myéloïdes. |
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AbstractList | The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human PILRA and compositions comprising such antibodies or antigen-binding fragments thereof. In a particular aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human PILRA block binding of PILRA to ligand and/or decrease cell surface PILRA. In further aspects, the antibodies or antigen-binding fragments can be used to treat diseases or conditions associated with myeloid cell dysfunction.
La présente invention concerne des anticorps et des fragments de liaison à l'antigène associés qui se lient spécifiquement à PILRA humain ainsi que des compositions comprenant de tels anticorps ou fragments de liaison à l'antigène associés. Dans un aspect particulier, les anticorps ou fragments de liaison à l'antigène de ceux-ci qui se lient spécifiquement à PILRA humain, bloquent la liaison de PILRA à un ligand et/ou diminuent PILRA sur la surface cellulaire. Dans d'autres aspects, les anticorps ou fragments de liaison à l'antigène peuvent être utilisés pour traiter des maladies ou des affections associées à un dysfonctionnement des cellules myéloïdes. |
Author | NALLE, SAMUEL LEUNG, LING LIANG, SPENCER |
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DocumentTitleAlternate | ANTICORPS PILRA ET METHODES D'UTILISATION ASSOCIEES |
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Snippet | The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human PILRA and compositions comprising such... |
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SubjectTerms | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | PILRA ANTIBODIES AND METHODS OF USE THEREOF |
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