COMPOSITIONS FOR TRANSFECTING A NUCLEIC ACID MOLECULE INTO A CELL COMPRISING HETEROCYCLIC COMPOUNDS GRAFTED TO A CATIONIC POLYMER, AND THEIR APPLICATIONS
The present invention relates to compositions for transfecting a nucleic acid molecule into a cell and their applications. The present invention is directed to a composition suitable for transfecting a nucleic acid molecule into a cell, preferably a eukaryotic cell, comprising (i) at least one compo...
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Format | Patent |
Language | English French |
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11.02.2021
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Abstract | The present invention relates to compositions for transfecting a nucleic acid molecule into a cell and their applications. The present invention is directed to a composition suitable for transfecting a nucleic acid molecule into a cell, preferably a eukaryotic cell, comprising (i) at least one compound of general formula (II) or a tautomer, mesomer, racemate, enantiomer, diastereomer, or mixture thereof, or an acceptable salt thereof, and (ii) an acceptable excipient, buffering agent, cell culture medium, or transfection medium, wherein Y1, Y2, Y3, Z1, Z2, Z3, Z4, Z5, Z6, Z7, X1, X2, R3, P+, R, T, U and V are as defined in the description. The present invention also relates to uses of said composition and to a method for in vitro or ex vivo transfection of live cells.
La présente invention concerne des compositions pour la transfection d'une molécule d'acide nucléique dans une cellule et leurs applications. La présente invention concerne une composition appropriée pour transfecter une molécule d'acide nucléique dans une cellule, de préférence une cellule eucaryote, comprenant (i) au moins un composé de formule générale (II) ou un tautomère, un mésomère, un racémate, un énantiomère, un diastéréoisomère ou un mélange de ceux-ci, ou un sel acceptable de ceux-ci, et (ii) un excipient acceptable, un agent tampon, un milieu de culture cellulaire, ou un milieu de transfection, dans lequel Y1, Y2, Y3, Z1, Z2, Z3, Z4, Z5, Z6, Z7, X1, X2, R3, P+, R, T, U et V sont tels que définis dans la description. L'invention se rapporte également à des utilisations de ladite composition et à un procédé de transfection in vitro ou ex vivo de cellules vivantes. |
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AbstractList | The present invention relates to compositions for transfecting a nucleic acid molecule into a cell and their applications. The present invention is directed to a composition suitable for transfecting a nucleic acid molecule into a cell, preferably a eukaryotic cell, comprising (i) at least one compound of general formula (II) or a tautomer, mesomer, racemate, enantiomer, diastereomer, or mixture thereof, or an acceptable salt thereof, and (ii) an acceptable excipient, buffering agent, cell culture medium, or transfection medium, wherein Y1, Y2, Y3, Z1, Z2, Z3, Z4, Z5, Z6, Z7, X1, X2, R3, P+, R, T, U and V are as defined in the description. The present invention also relates to uses of said composition and to a method for in vitro or ex vivo transfection of live cells.
La présente invention concerne des compositions pour la transfection d'une molécule d'acide nucléique dans une cellule et leurs applications. La présente invention concerne une composition appropriée pour transfecter une molécule d'acide nucléique dans une cellule, de préférence une cellule eucaryote, comprenant (i) au moins un composé de formule générale (II) ou un tautomère, un mésomère, un racémate, un énantiomère, un diastéréoisomère ou un mélange de ceux-ci, ou un sel acceptable de ceux-ci, et (ii) un excipient acceptable, un agent tampon, un milieu de culture cellulaire, ou un milieu de transfection, dans lequel Y1, Y2, Y3, Z1, Z2, Z3, Z4, Z5, Z6, Z7, X1, X2, R3, P+, R, T, U et V sont tels que définis dans la description. L'invention se rapporte également à des utilisations de ladite composition et à un procédé de transfection in vitro ou ex vivo de cellules vivantes. |
Author | RICORDEL, MARINE STOCK, FABRICE PREMARTIN, FANNY TOUSSAINT MOREAU, VALERIE PHILIPSON, YANN PORTE, MATHIEU ERBACHER, PATRICK BENCHIMOL, THIBAUT HAVARD, JONATHAN HELLAL, MALIK DENU, MEGANE |
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DocumentTitleAlternate | COMPOSITIONS POUR LA TRANSFECTION D'UNE MOLECULE D'ACIDE NUCLEIQUE DANS UNE CELLULE COMPRENANT DES COMPOSES HETEROCYCLIQUES GREFFES A UN POLYMERE CATIONIQUE ET LEURS APPLICATIONS |
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Snippet | The present invention relates to compositions for transfecting a nucleic acid molecule into a cell and their applications. The present invention is directed to... |
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Title | COMPOSITIONS FOR TRANSFECTING A NUCLEIC ACID MOLECULE INTO A CELL COMPRISING HETEROCYCLIC COMPOUNDS GRAFTED TO A CATIONIC POLYMER, AND THEIR APPLICATIONS |
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