TRISPECIFIC ANTIGEN BINDING PROTEINS

Trispecific antigen-binding proteins including: a first binding domain capable of binding to a cell surface protein of a tumor cell; a second binding domain capable of binding to a cell surface immune checkpoint protein of the tumor cell; and a third binding domain capable of binding to a cell surfa...

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Main Authors LEISNER, CHRISTIAN VALDEMAR VINGE, SCHLEIER, THOMAS, RICHLE, PHILIPP ROBERT, ESCHER, DOMINIK, SCHEIFELE, FABIAN, BORRAS, LEONARDO
Format Patent
LanguageEnglish
French
Published 06.09.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Trispecific antigen-binding proteins including: a first binding domain capable of binding to a cell surface protein of a tumor cell; a second binding domain capable of binding to a cell surface immune checkpoint protein of the tumor cell; and a third binding domain capable of binding to a cell surface protein of an immune cell, are provided. Methods of making trispecific antigen-binding proteins are provided. Des protéines de liaison à un antigène trispécifiques comprennent : un premier domaine de liaison capable de se lier à une protéine de surface cellulaire d'une cellule tumorale; un deuxième domaine de liaison capable de se lier à une protéine de point de contrôle immunitaire de surface cellulaire de la cellule tumorale; et un troisième domaine de liaison capable de se lier à une protéine de surface cellulaire d'une cellule immunitaire. L'invention concerne également des procédés de fabrication de protéines de liaison à un antigène trispécifiques.
Bibliography:Application Number: CA20193089230