SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS

• Main Authors: BLAKE, JAMES F, PRIGARO, BRETT, JIANG, YUTONG, MCKENNEY, MEGAN L, RAMANN, GINELLE A, METCALF, ANDREW T, REN, LI, KOLAKOWSKI, GABRIELLE R, MORENO, DAVID A, DAI, DONGHUA, HAAS, JULIA, MCFADDIN, ELIZABETH A
• Format: Patent
• Language: English; French
• Published: 25.07.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are compounds of the Formula I: [INSERT FORMULA I] and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2 and Ry have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. La présente invention concerne des composés de formule I : ainsi que tautomères, des stéréoisomères et des sels et solvates pharmaceutiquement acceptables de ceux-ci, R1, R2 et Ry ayant les significations données dans la description, qui sont des inhibiteurs de la kinase RET et sont utiles dans le traitement et la prévention de maladies pouvant être traitées avec un inhibiteur de la kinase RET, notamment des maladies associées à RET.