SPIROCYCLIC INDOLINES AS IL-17 MODULATORS

A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders. Selon l'invention, une...

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Main Authors LECOMTE, FABIEN CLAUDE, FOLEY, ANNE MARIE, TAYLOR, RICHARD DAVID, SELBY, MATTHEW DUNCAN, TOWNSEND, ROBERT JAMES, CHAPPELL, ROSE ELIZABETH, SCHULZE, MONIKA-SARAH ELISABETH DOROTHEA, FOULKES, GREGORY, QUINCEY, JOANNA RACHEL, ZHU, ZHAONING, JONES, ELIZABETH PEARL, SMALLEY, ADAM PETER, BRACE, GARETH NEIL, DEBOVES, HERVE JEAN CLAUDE
Format Patent
LanguageEnglish
French
Published 20.12.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders. Selon l'invention, une série de dérivés de 2-oxoindolines spirocycliques substituées, et des analogues de ceux-ci, sont des modulateurs puissants de l'activité de l'IL-17 humaine, et sont donc utiles dans le traitement et/ou la prévention de diverses maladies humaines, notamment des troubles inflammatoires et auto-immuns.
Bibliography:Application Number: CA20183064156