PYRIMIDO[5,4-B]INDOLIZINE OR PYRIMIDO[5,4-B]PYRROLIZINE COMPOUND, PREPARATION METHOD AND USE THEREOF

• Main Authors: ZHANG, AO, XIE, HUA, SONG, ZILAN, TONG, LINJIANG, XUE, YU, DING, JIAN, GENG, MEIYU
• Format: Patent
• Language: English; French
• Published: 31.05.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pyrimido[5,4-b]indolizine or pyrimido[5,4-b]pyrrolizine compound, a preparation method and a use thereof. The compound of the present invention has good inhibitory activity on BTK both at the molecular level and the cellular level. Importantly, the compound of the...