SCALABLE PROCESS FOR ONCOLYTIC RAT PARVOVIRUS H-1 PRODUCTION AND PURIFICATION BASED ON ISOELECTRIC POINT-BASED ELIMINATION OF EMPTY PARTICLES

The present invention provides a reproducible, effective and scalable process for the purification of (infectious) parvovirus H-1 particles. The purification process allows the separation of empty particles from particles containing a full genome and is compatible with large-scale H-1PV production f...

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Bibliographic Details
Main Authors RIESE, MARKUS, LEUCHS, BARBARA, FREHTMAN, VERONIKA, ROMMELAERE, JEAN
Format Patent
LanguageEnglish
French
Published 12.09.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention provides a reproducible, effective and scalable process for the purification of (infectious) parvovirus H-1 particles. The purification process allows the separation of empty particles from particles containing a full genome and is compatible with large-scale H-1PV production for clinical applications. La présente invention concerne un procédé reproductible, efficace et évolutif pour la purification de particules de parvovirus H-1 (infectieuses). Le procédé de purification permet la séparation de particules vides de particules contenant un génome complet et est compatible avec la production de PV H-1 à grande échelle pour des applications cliniques.
Bibliography:Application Number: CA20173042985