BIOSYNTHESIS OF BENZYLISOQUINOLINE ALKALOIDS AND BENZYLISOQUINOLINE ALKALOID PRECURSORS

Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to have reduced levels or activity of one or more alcohol dehydrogenases or aldehyde reductases thereby increasing the production of benzylisoquinoline alkaloids and/or benzylisoquinoline alkaloid precursors....

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Main Authors HANSEN, ESBEN HALKJAER, SCHWAB, MARKUS, BERNINGER, PHILIPP, GRASSINGER, FRANZISKA, DELGRANGE, FANNY
Format Patent
LanguageEnglish
French
Published 15.02.2018
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to have reduced levels or activity of one or more alcohol dehydrogenases or aldehyde reductases thereby increasing the production of benzylisoquinoline alkaloids and/or benzylisoquinoline alkaloid precursors. L'invention concerne des microorganismes de recombinaison, des plantes et des cellules végétales, qui ont été modifiés de manière à présenter des taux réduits ou une activité réduite d'un ou plusieurs alcool déshydrogénases ou aldéhyde réductases, de manière à ainsi accroître la production d'alcaloïdes de benzylisoquinoline et/ou de précurseurs d'alcaloïdes de benzylisoquinoline.
Bibliography:Application Number: CA20173033246