LSD1 INHIBITORS

Lysine-specific demethylase one (LSD1) has been found to be overexpressed in some cancers. The present invention relates to compounds that inhibit LSD1 activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating can...

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Bibliographic Details
Main Authors GALEMMO, ROBERT ANTHONY, MARX, MATTHEW ARNOLD, CHRISTENSEN, JAMES GAIL, VAISBURG, ARKADII
Format Patent
LanguageEnglish
French
Published 17.10.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Lysine-specific demethylase one (LSD1) has been found to be overexpressed in some cancers. The present invention relates to compounds that inhibit LSD1 activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention. In certain examples, the compounds are represented by the following formulae: La déméthylase 1 spécifique de la lysine s'avère surexprimée dans certains cancers. La présente invention concerne des composés qui inhibent l'activité de déméthylase 1 spécifique de la lysine. En particulier, la présente invention concerne des composés, des compositions pharmaceutiques et des procédés d'utilisation tels que des méthodes de traitement du cancer utilisant les composés et les compositions pharmaceutiques de la présente invention. Selon certains exemples, les composés sont représentés par les formules suivantes :
Bibliography:Application Number: CA20163009805