BISPECIFIC ANTIBODY CONSTRUCTS BINDING EGFRVIII AND CD3

• Main Authors: RAU, DORIS, POMPE, CORNELIUS, KUFER, PETER, HOFFMANN, PATRICK, BOGNER, PAMELA, RAUM, TOBIAS, WOLF, ANDREAS, MUENZ, MARKUS, FRIEDRICH, MATTHIAS, RATTEL, BENNO, HERRMANN, INES, BROZY, JOHANNES
• Format: Patent
• Language: English; French
• Published: 13.02.2024
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human EGFRVIII on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding...