BISPECIFIC ANTIBODY CONSTRUCTS BINDING EGFRVIII AND CD3
The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human EGFRVIII on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding...
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| Main Authors | , , , , , , , , , , , |
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| Format | Patent |
| Language | English French |
| Published |
13.02.2024
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| Abstract | The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human EGFRVIII on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
La présente invention concerne une construction d'anticorps bispécifique comprenant un premier domaine de liaison qui se lie à l'EGFRVIII humain sur la surface d'une cellule cible et un second domaine de liaison qui se lie au CD3 humain sur la surface d'un lymphocyte T. De plus, l'invention concerne un polynucléotide codant pour la construction d'anticorps, un vecteur comprenant ledit polynucléotide et une cellule hôte transformée ou transfectée avec ledit polynucléotide ou vecteur. Un procédé de production de la construction d'anticorps selon l'invention, un usage médical de ladite construction d'anticorps et un kit la comprenant sont en outre décrits. |
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| AbstractList | The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human EGFRVIII on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
La présente invention concerne une construction d'anticorps bispécifique comprenant un premier domaine de liaison qui se lie à l'EGFRVIII humain sur la surface d'une cellule cible et un second domaine de liaison qui se lie au CD3 humain sur la surface d'un lymphocyte T. De plus, l'invention concerne un polynucléotide codant pour la construction d'anticorps, un vecteur comprenant ledit polynucléotide et une cellule hôte transformée ou transfectée avec ledit polynucléotide ou vecteur. Un procédé de production de la construction d'anticorps selon l'invention, un usage médical de ladite construction d'anticorps et un kit la comprenant sont en outre décrits. |
| Author | POMPE, CORNELIUS RATTEL, BENNO FRIEDRICH, MATTHIAS RAUM, TOBIAS HERRMANN, INES KUFER, PETER BROZY, JOHANNES WOLF, ANDREAS MUENZ, MARKUS RAU, DORIS BOGNER, PAMELA HOFFMANN, PATRICK |
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| DocumentTitleAlternate | CONSTRUCTIONS D'ANTICORPS BISPECIFIQUES SE LIANT A L'EGFRVIII ET A CD3 |
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| Snippet | The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human EGFRVIII on the surface of a target... |
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| Title | BISPECIFIC ANTIBODY CONSTRUCTS BINDING EGFRVIII AND CD3 |
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