ANTI-MUC16 ANTIBODIES AND USES THEREOF

• Main Authors: SPRIGGS, DAVID, FERNANDEZ-TEJADA, ALBERTO, THAPI, DHARMARAO
• Format: Patent
• Language: English; French
• Published: 22.09.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided herein are compositions, methods, and uses involving antibodies that immunospecifically bind glycosylated forms of MUC16, a tethered mucin protein. Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer. L'invention concerne des compositions, des procédés et des utilisations impliquant des anticorps qui se lient immunospécifiquement à des formes glycosylées de MUC16, une protéine mucine fixée. L'invention concerne également des utilisations et des procédés permettant de gérer, de traiter ou de prévenir des troubles, tels que le cancer.