ISOTOPOLOGUES OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE

Provided herein are isotopologues of Compound A having the structure as shown below, which are enriched with isotopes such as, for example, deuterium. Pharmaceutical compositions comprising the isotope-enriched compounds, and methods of using such compounds are also provided. Embodiments provided he...

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Bibliographic Details
Main Authors KOTHARE, MOHIT ATUL, MAN, HON-WAH
Format Patent
LanguageEnglish
French
Published 04.08.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Provided herein are isotopologues of Compound A having the structure as shown below, which are enriched with isotopes such as, for example, deuterium. Pharmaceutical compositions comprising the isotope-enriched compounds, and methods of using such compounds are also provided. Embodiments provided herein encompass isotopologues of Compound A and pharmaceutically acceptable salts, stereoisomers, tautomers, solid forms, polymorphs, hydrates, clathrates, and solvates thereof. Des isotopologues de composé A comprennent la structure montrée c-dessous, lesquels isotopologues sont enrichis d'isotopes de deutérium, par exemple. Des compositions pharmaceutiques comprenant des composés enrichis d'isotopes et des méthodes d'utilisation de tels composés sont décrites. Des modes de réalisation regroupent des isotopologues de composé A et des sels acceptables sur le plan pharmaceutique, des stéréoisomères, des tautomères, des formes solides, des polymorphes, des hydrates, des clathrates et des solvates connexes.
Bibliography:Application Number: CA20162975260