CATIONIC LIPID FOR NUCLEIC ACID DELIVERY

An object of the present invention is to provide a cationic lipid capable of achieving higher intracellular delivery efficiency than conventional cationic lipids, when used as a lipid membrane structure which is a carrier for delivering functional nucleic acid. A cationic lipid represented by the fo...

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Main Authors HATAKEYAMA, HIROTO, AKITA, HIDETAKA, OTA, MASAKI, SHIMIZU, NAYUTA, KUBO, KAZUHIRO, NAKAI, YUTA, HARASHIMA, HIDEYOSHI, TANGE, KOTA, SASAKI, SHOTA, NOGUCHI, YUKI
Format Patent
LanguageEnglish
French
Published 25.02.2016
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:An object of the present invention is to provide a cationic lipid capable of achieving higher intracellular delivery efficiency than conventional cationic lipids, when used as a lipid membrane structure which is a carrier for delivering functional nucleic acid. A cationic lipid represented by the formula (1): (see formula 1) wherein each symbol is as defined in the present DESCRIPTION. La présente invention concerne un lipide cationique qui, lorsqu'il est utilisé sous la forme d'une structure de membrane lipidique laquelle est un support pour l'administration d'acide nucléique fonctionnel, permet d'obtenir une plus grande efficacité d'administration intracellulaire qu'avec un lipide cationique classique. Le lipide cationique est représenté par la formule (1). (Dans la formule, chaque symbole est tel que défini dans la présente description.)
Bibliography:Application Number: CA20152958542