PHARMACEUTICAL FORMULATIONS FOR SUBCUTANEOUS ADMINISTRATION OF FUROSEMIDE
The present teachings relate to liquid pharmaceutical formulations of furosemide, where the pharmaceutical formulations include a molar excess of tris(hydroxymethyl)aminomethane to furosemide, have a pH in the range of 7 to 8.5, and a concentration of tris(hydroxymethyl)aminomethane greater than or...
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| Main Authors | , , |
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| Format | Patent |
| Language | English French |
| Published |
15.06.2021
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| Abstract | The present teachings relate to liquid pharmaceutical formulations of furosemide, where the pharmaceutical formulations include a molar excess of tris(hydroxymethyl)aminomethane to furosemide, have a pH in the range of 7 to 8.5, and a concentration of tris(hydroxymethyl)aminomethane greater than or equal to about 50 mM. The present teachings can improve the stability of liquid pharmaceutical formulations including furosemide and the suitability of such pharmaceutical formulations for subcutaneous administration or delivery.
La présente invention concerne des formulations pharmaceutiques liquides de furosémide. Lesdites formulations pharmaceutiques incluent un excès molaire de tris(hydroxyméthyl)aminométhane par rapport au furosémide, et présentent un pH situé dans la plage de 7 à 8,5 et une concentration de tris(hydroxyméthyl)aminométhane supérieure ou égale à environ 50 mM. La présente invention permet d'améliorer la stabilité de formulations pharmaceutiques liquides incluant du furosémide et l'aptitude à l'usage de ces formulations pharmaceutiques pour leur administration ou leur apport sous-cutané. |
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| AbstractList | The present teachings relate to liquid pharmaceutical formulations of furosemide, where the pharmaceutical formulations include a molar excess of tris(hydroxymethyl)aminomethane to furosemide, have a pH in the range of 7 to 8.5, and a concentration of tris(hydroxymethyl)aminomethane greater than or equal to about 50 mM. The present teachings can improve the stability of liquid pharmaceutical formulations including furosemide and the suitability of such pharmaceutical formulations for subcutaneous administration or delivery.
La présente invention concerne des formulations pharmaceutiques liquides de furosémide. Lesdites formulations pharmaceutiques incluent un excès molaire de tris(hydroxyméthyl)aminométhane par rapport au furosémide, et présentent un pH situé dans la plage de 7 à 8,5 et une concentration de tris(hydroxyméthyl)aminométhane supérieure ou égale à environ 50 mM. La présente invention permet d'améliorer la stabilité de formulations pharmaceutiques liquides incluant du furosémide et l'aptitude à l'usage de ces formulations pharmaceutiques pour leur administration ou leur apport sous-cutané. |
| Author | LARSEN, GLENN R MUNTENDAM, PIETER MICHAELS, SCOTT A |
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| DocumentTitleAlternate | FORMULATIONS PHARMACEUTIQUES POUR L'ADMINISTRATION SOUS-CUTANEE DE FUROSEMIDE |
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| Snippet | The present teachings relate to liquid pharmaceutical formulations of furosemide, where the pharmaceutical formulations include a molar excess of... |
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| Title | PHARMACEUTICAL FORMULATIONS FOR SUBCUTANEOUS ADMINISTRATION OF FUROSEMIDE |
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