PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS

Process methods for making the dual m TOR/PI3K inhibitor GDC-0980, named as (S)-1- (4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6- yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceuticall...

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Main Authors GOSSELIN, FRANCIS, HIDBER, PIRMIN, HUMPHRIES, THERESA, YAJIMA, HERBERT, BABU, SRINIVASAN, REENTS, REINHARD, TIAN, QINGPING, CHENG, ZHIGANG, HOFFMANN, URSULA
Format Patent
LanguageEnglish
French
Published 17.04.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract Process methods for making the dual m TOR/PI3K inhibitor GDC-0980, named as (S)-1- (4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6- yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.
AbstractList Process methods for making the dual m TOR/PI3K inhibitor GDC-0980, named as (S)-1- (4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6- yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.
Author CHENG, ZHIGANG
HOFFMANN, URSULA
YAJIMA, HERBERT
BABU, SRINIVASAN
HUMPHRIES, THERESA
REENTS, REINHARD
HIDBER, PIRMIN
TIAN, QINGPING
GOSSELIN, FRANCIS
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– fullname: HUMPHRIES, THERESA
– fullname: YAJIMA, HERBERT
– fullname: BABU, SRINIVASAN
– fullname: REENTS, REINHARD
– fullname: TIAN, QINGPING
– fullname: CHENG, ZHIGANG
– fullname: HOFFMANN, URSULA
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DocumentTitleAlternate PROCEDE DE PREPARATION DE COMPOSES DE THIENOPYRIMIDINE
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Snippet Process methods for making the dual m TOR/PI3K inhibitor GDC-0980, named as (S)-1-...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS
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