DR5 LIGAND DRUG CONJUGATES

• Main Authors: OHTSUKA, TOSHIAKI, ICHIKAWA, KIMIHISA, YADA, AYUMI
• Format: Patent
• Language: English; French
• Published: 31.10.2013
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Ligand Drug Conjugates are provided having a DRS binding moiety attached via linking groups and/or spacers to a therapeutic agent that are effective in treatment of various cancers. In some embodiments, the Ligand Drug Conjugate has the formula: L-(LU-D)p, where L is a Ligand unit, LU is a Linker un...