SUBSTITUTED BENZYLAMINE COMPOUNDS, THEIR USE IN MEDICINE, AND IN PARTICULAR THE TREATMENT OF HEPATITIS C VIRUS (HCV) INFECTION

• Main Authors: CHESSARI, GIANNI, REES, DAVID CHARLES, BESONG, GILBERT EBAI, SAALAU-BETHELL, SUSANNE MARIA, THOMPSON, NEIL THOMAS, O'BRIEN, MICHAEL ALISTAIR, WILLEMS, HENDRIKA MARIA GERARDA, WOODHEAD, ANDREW JAMES, CARR, MARIA GRAZIA, HISCOCK, STEVEN DOUGLAS
• Format: Patent
• Language: English; French
• Published: 10.05.2013
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides compounds of the formula (I): or a salt, N-oxide or tautomer thereof, wherein A is CH, CF or nitrogen; E is CH, CF or nitrogen; and R0 is hydrogen or C1-2 alkyl; R1a is selected from CONH2; CO2H; an optionally substituted acyclic C1-8 hydrocarbon group; and an optionally subst...